4-Diethylaminobenzaldehyde 是醛脱氢酶(ALDHs)的可逆抑制剂,对 ALDH1 的Ki为 4 nM,具有较强的抗雄激素作用 ,IC50为1.71 μM。
产品描述
4-Diethylaminobenzaldehyde is a reversible aldehyde dehydrogenase (ALDH) inhibitor (Ki: 4 nM for ALDH1). It displays a potent anti-androgenic effect (IC50: 1.71μM).
体外活性
4-Diethylaminobenzaldehyde (DEAB) is reversible competitive inhibitor of ALDH1 (competitive with the aldehyde substrate) with a Ki value of 4 nM,?,DEAB irreversibly inactivates ALDH7A1 via formation of a stable, covalent acyl-enzyme species[1].
Cas No.
120-21-8
分子式
C11H15NO
分子量
177.24
别名
4-Diethylaminobenzaldehyde
储存和溶解度
DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years