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BPH-1358
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BPH-1358图片
CAS NO:5352-53-4
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议

产品名称
NSC50460
产品介绍
BPH-1358 是一种人FPPS和UPPS抑制剂,IC50值分别为 1.8 μM 和 110 nM,对金黄色葡萄球菌的 MIC 值大约为 250 ng/mL。

产品描述

BPH-1358 (NSC50460) is a potent human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) inhibitor. With IC50s of 1.8 μM and 110 nM, respectively. And it is active against S. aureus in vitro (MIC ~250 ng/mL)[1][2].

体外活性

BPH-1358 against E. coli and S. aureus with EC50 of 300 nM and 290 nM, respectively[1]. BPH-1358 is the most potent inhibitor of both E. coli UPPS (EcUPPS) as well as S. aureus UPPS (SaUPPS), with an IC50 of 110 nM.

体内活性

BPH-1358 is active against S. aureus in vivo (20/20 mice survived an intraperitoneal infection model of MRSA strain)[1].

Cas No.

5352-53-4

分子式

C32H30Cl2N6O2

分子量

601.53

别名

NSC50460;BPH-1358

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years