您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Adarotene
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Adarotene
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Adarotene图片
CAS NO:496868-77-0
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
ST1926
产品介绍
Adarotene 是一种细胞凋亡诱导剂,通过产生 DNA 损伤,来阻止人类肿瘤细胞的增殖。

产品描述

Adarotene is an effective apoptosis inducer. It surprisingly produces DNA damage and exhibits a potent antiproliferative activity on a large panel of human tumor cells.

体外活性

Adarotene causes cell accumulation in the G1/S or S phase of the cell cycle depending on tumor cells IGROV-1 and DU145. Adarotene causes dose-dependent growth inhibition in a large panel of human tumor cell lines with IC50 ranging from 0.1 to 0.3 μM [1]. Adarotene is apoptotic and cytotoxic on a large spectrum of cancerous and leukemic cells, including freshly isolated AML blasts in primary culture. Adarotene treatment of cells results in rapid accumulation of intracellular calcium [2].

体内活性

Adarotene (30, 40 mg/kg, p.o.) causes a significant and dose-dependent increase in the life span of NB4-bearing SCID mice without overt toxicity [2]. Adarotene (15, 20 mg/kg, p.o.) leads to a significant tumor growth inhibition in a human ovarian carcinoma, A2780/DX, and in human melanoma, MeWo, growing in nude mice [1].

Cas No.

496868-77-0

分子式

C25H26O3

分子量

374.47

别名

ST1926;Adarotene

储存和溶解度

DMSO:25 mg/mL (66.76 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years