您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > IRAK4-IN-15
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
IRAK4-IN-15
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:2667681-85-6
包装与价格:
包装价格(元)
5 mg电议
50 mg电议
100 mg电议

产品介绍
IRAK4-IN-15 (compound 35) 是一种有效的选择性IRAK4抑制剂,IC50为 0.002 μM。IRAK4-IN-15 显示出良好的人类 PK 预测且具有低内在清除率。IRAK4-IN-15 与 Acalabrutinib 联用显示出对 MyD88/CD79 双突变体 ABC-DLBCL 的显著协同体外活性。

产品描述

IRAK4-IN-15 (compound 35) is a potent and selective IRAK4 inhibitor with an IC 50 of 0.002 μM. IRAK4-IN-15 shows good human PK predictions with low intrinsic clearance. IRAK4-IN-15 shows great synergistic in vitro activity against MyD88/CD79 double mutant ABC-DLBCL in combination with Acalabrutinib. [1].

体外活性

IRAK4-IN-15 (compound 35) shows cell pIRAK4 potencies with an IC 50 of 0.21 μM [1]. IRAK4-IN-15 (compound 35) shows selectivity with IC 50 s of 0.002,1.2, >10,1.5, 0.23, 0.48, 0.93, 0.57 μM for IRAK4, IRAK1, BTK, Flt3, PI3Kδ, TRKa, TRKb, TRKc, respectively [1].

Cas No.

2667681-85-6

分子式

C25H29FN10

分子量

488.56

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years