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Guaifenesin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Guaifenesin图片
CAS NO:93-14-1
包装与价格:
包装价格(元)
500 mg电议
1 g电议
1 mL*10 mM(in DMSO)电议

产品名称
愈创甘油醚
Guaiphenesin
Guaiacol glyceryl ether
Glycerol guaiacolate
产品介绍
Guaifenesin 是一种祛痰剂,来自于 Guajacum officinale Linné 木材中。它可以增加痰液体积和降低其粘度,缓解咳嗽不适,促进有效的咳嗽。

产品描述

Guaifenesin is an expectorant that also has some muscle relaxing action. It is used in many cough preparations.

体内活性

Guaifenesin (200 mg/kg, intravenously) combined with ketamine (50 mg/kg, intramuscularly) produces effective and safe surgical anesthesia for over 30 minutes in New Zealand white rabbits. Guaifenesin (200 mg/kg, intravenously) combined with ketamine (50 mg/kg, intramuscularly) mildly depresses respiratory rate but heart rate and arterial blood pressure are not significantly affected. Guaifenesin (200 mg/kg, intravenously) is combined with sodium pentobarbital (20 mg/kg, intravenously) to produce surgical anesthesia for a period of more than 30 minutes. [1] Guaifenesin (50 mg/mL) combined Xylazine (0.1 mg/mL) and Ketamine (1.0 mg/mL) results in excellent anesthetic induction and maintenance with cardiopulmonary alterations similar to those associated with isoflurane in mechanically ventilated calves. [2] Guaifenesin (150 mg/kg) decreases spectral edge frequency (SEF) and total power in pigs. [3] Guaifenesin prevents adverse anesthetic induction events caused by Propofol in horse. Guaifenesin (90 mg/kg) followed by Propofol (3 mg/kg) should be sufficient to immobilize >99% of calm healthy adult horses. [4] Guaifenesin (100 mg/kg) produces moderate behavioral changes in the social conflict test in mice. Guaifenesin (200 mg/kg) combined with Paracetamol (200 mg/kg) causes significantly more pronounced analgesic effects that the corresponding doses of paracetamol alone in mice. [5]

Cas No.

93-14-1

分子式

C10H14O4

分子量

198.218

别名

愈创甘油醚;Guaiphenesin;Guaiacol glyceryl ether;Glycerol guaiacolate;Guaifenesin

储存和溶解度

DMSO:38 mg/mL (191.7 mM)
H2O:23 mg/mL (116 mM)
Ethanol:38 mg/mL (191.7 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years