Nebracetam hydrochloride 是促智 M1-毒蕈碱的激动剂。 它诱导细胞内 Ca2+ 浓度升高, EC50 为 1.59 mM。
产品描述
Nebracetam hydrochloride is an agonist nootropic M1-muscarinic. Nebracetam hydrochloride induces a rise of intracellular Ca2+ concentration. Nebracetam hydrochloride exhibits an EC50 of 1.59 mM for elevating [Ca2+]i.
体外活性
Nebracetam involves not only cholinergic mechanisms but also involves lymbic and hippocampal noradrenergic mechanisms.
动物实验
Nebracetam (WEB 1881 FU), a new nootropic candidate, was able to correct this scopolamine-induced disruption of spatial cognition at the dose of 10 mg/kg, p.o in male Wistar rats weighing 200-250 g [2].
Cas No.
1177279-49-0
分子式
C12H17ClN2O
分子量
240.73
别名
WEB 1881 FU hydrochloride;Nebracetam hydrochloride
储存和溶解度
DMSO:99 mg/mL (411.24 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years