L-Cysteinesulfinic acid monohydrate 是代谢型谷氨酸受体 (mGluRs) 的有效激动剂，可以作用于 mGluR1，mGluR2，mGluR5，mGluR4，mGluR6 和 mGluR8，pEC50分别为 3.92，3.9，4.6，2.7，4.0，和 3.94。

L-Cysteinesulfinic acid monohydrate is a potent agonist at rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively[1].

L-Cysteinesulfinic acid (monohydrate) is an endogenous agonist of a metabotropic receptor coupled to stimulation of phospholipase D (PLD) activity. L-CSA (monohydrate) is an endogenous agonist of the PLD-coupled metabotropic excitatory amino acids (EAA) receptor. L-CSA (monohydrate) selectively activates the PLD-coupled receptor. 1 mM L-CSA (monohydrate) induces a significant increase in PLD activity in hippocampal slices, whereas 1 mM concentrations of L-glutamate, L-aspartate, and L-HCA are without effect. L-CSA (monohydrate) elicits a dose-dependent increase in PLD activity in rat hippocampal slices in the presence of iGluR antagonists, with an approximate EC50 of 500 uM. The PLD response induced by 1 mM L-CSA (monohydrate) is not significantly decreased in the presence of 1 uM tetrodotoxin, suggesting that this response is not dependent upon L-CSA (monohydrate)-induced increases in cell firing[1].

207121-48-0

C3H9NO5S

171.17

L-Cysteinesulfinic acid monohydrate

H2O:120 mg/mL (701.06 mM),Need ultrasonic
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In solvent: -80°C for 2 years