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Doxylamine Succinate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Doxylamine Succinate图片
CAS NO:562-10-7
包装与价格:
包装价格(元)
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Decapryn
琥珀酸多西拉敏
产品介绍
Doxylamine succinate 是一种吡啶衍生物组胺 H1 拮抗剂,具有明显的镇静特性。它竞争性阻断组胺 H1 受体并限制典型的过敏和过敏反应,可防止组胺引起的皮肤和粘膜疼痛和瘙痒。

产品描述

Doxylamine Succinate is a pyridine derivate histamine H1 antagonist with pronounced sedative properties. Doxylamine succinate competitively blocks the histamine H1 receptor and limits the typical allergic and anaphylactic responses, including bronchoconstriction, vasodilation, increased capillary permeability, and spasmodic contraction of the gastrointestinal smooth muscle, caused by actions of histamine on bronchial and gastrointestinal smooth muscles, and on capillaries. This drug also prevents histamine-induced pain and itching of the skin and mucous membranes.

体外活性

在B6C3F1小鼠体内,以Doxylamine琥珀酸盐形式,食物摄取7天或15天(饮食中含量0, 40, 375, 750, or 1500 ppm, 以游离碱Doxylamine形式)的方式考察了Doxylamine对微粒体酶活性和血清甲状腺激素水平的影响.结果发现在B6C3F1小鼠体内,Doxylamine是肝微粒体细胞色素P450?的巴比妥类诱导剂,且与Doxylamine提升了参与T4代谢的肝酶活性的假说相一致.

Cas No.

562-10-7

分子式

C21H28N2O5

分子量

388.464

别名

Decapryn;琥珀酸多西拉敏;Doxylamine succinate

储存和溶解度

DMSO:100 mg/mL (257.43 mM)
H2O:100 mg/mL (257.43 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years