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LR-90
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LR-90图片
CAS NO:245075-84-7
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
LR-90 是一种晚期糖基化终产物抑制剂,能够抑制人单核细胞的炎症反应,也可用于研究糖尿病动物模型。

产品描述

LR-90 is also used in the research of diabetic animal model.LR-90 is an advanced glycation end product (AGE) inhibitor, inhibits inflammatory responses in human monocytes.

体外活性

LR-90 (0, 25, 50, 100, and 200 μM) dose-dependently and significantly blocks THP-1 cells adherence to endothelial cells after pretreatment 1 h befor S100b stimulatation for 24 hours[1].?LR-90 (0, 25, 50, 100, and 200 μM, for 24 hours) shows no effect on the cell viability of THP-1 cells[1].LR-90 (0, 25, 50, 100, and 200 μM) inhibits RAGE, MCP-1, COX-2, IP-10 and NOX2 mRNA expression in THP-1 cells in a dose-dependent manner, after pretreatment 1 h befor S100b stimulatation for 4 hours[1].

体内活性

LR-90 (50 mg/L) decreases renal AGE, AGER and lipid peroxidation[2].LR-90 (50 mg/L, p.o. for 27 weeks) significantly reduces plasma lipids, modestly affects hyperglycaemia in ZDF rats[2].

Cas No.

245075-84-7

分子式

C35H34Cl2N4O8

分子量

709.57

别名

LR-90

储存和溶解度

DMSO:95 mg/mL (133.88 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years