ML-180 是孤儿核受体肝受体同源物 1 (LRH-1;NR5A2) 的反向激动剂(IC50:3.7 μM)。它不抑制类固醇生成因子 1 (SF-1;NR5A1; IC50>10 μM)。 它具有潜在的抗依赖 LRH-1 癌症作用。

ML-180 is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) inverse agonist (IC50 of 3.7 μM) .

ML-180 (0.5-5 μM; 24 hours) shows a significant inhibition of cyclin-D1 and cyclin-E1 expression in hepatic cells, but has little effect on repression in SK-OV-3 cells[2]. ML-180 (5 μM; 24 hours) leads to a rapid decrease of LRH-1 expression and efficiently represses endogenous LRH-1 signaling[2].

ML-180 has a statistically significant decrease of both LRH-1 and SHP mRNA in adrenal glands and pancreatic tissue[2].

863588-32-3

C20H25ClN4O2

388.89

SR1848;ML-180

DMSO:11 mg/mL (28.28 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years