您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > StemRegenin 1(hydrochloride)
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
StemRegenin 1(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
StemRegenin 1(hydrochloride)图片
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议

产品名称
StemRegenin 1 (hydrochloride) (1227633-49-9 free base)
StemRegenin 1 (hydrochloride)
产品介绍

产品描述

StemRegenin 1 is an aryl hydrocarbon receptor signaling antagonist (IC50: 127 nM in CD34+ cells).

体外活性

In vitro: In a previous study, the unbiased screen with primary human HSCs identified the StemRegenin 1 (SR1), which could promote the ex-vivo expansion of CD34+ cells. In addition, the culture of HSCs with SR1 resulted in a 50-fold increase in cells expressing CD34. Moreover, the mechanistic studies showed that SR1 acted by antagonizing the AhR [1].

体内活性

In vivo: In an animal study, 300 to 30,000 uncultured CB CD34+ cells were transplanted into NSG mice. Results showed that CB CD34+ cells cultured with SR1 led to significant increases in human engraftment in the peripheral blood at 1 week, compared with mice transplanted with 10,000 uncultured cells or the progeny of 10,000 control cells [1].

Cas No.

T23400

分子式

C24H23N5OS·HCl

分子量

466

别名

StemRegenin 1 (hydrochloride) (1227633-49-9 free base);StemRegenin 1 (hydrochloride)

储存和溶解度

DMSO:≤5mg/ml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years