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Gliotoxin-13C13
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Gliotoxin-13C13图片
包装:1 mg
市场价:-1元

产品介绍

产品描述

Gliotoxin-13C13is intended for use as an internal standard for the quantification of gliotoxin by GC- or LC-MS. Gliotoxin is an immunosuppressive mycotoxin produced by pathogenic strains ofAspergillusand other fungi with diverse biological activities.1,2,3,4,5,6,7,8It inhibits 20S proteasomal chymotrypsin activity (IC50= 10 μM), blocking the degradation of IκBα and preventing the activation of NF-κB.2,3Gliotoxin induces apoptosis in monocytes and dendritic cells and reduces phagocytosis by neutrophils.4,5It suppresses viral infection by Nipah and Hendra virus in HEK293T cells (IC50s = 149 and 579 nM, respectively).6Under reducing conditions, gliotoxin inhibits leukotriene A4hydrolase epoxide hydrolase activity, but not aminopeptidase activity, and leukotriene B4synthesis in neutrophils and monocytes.7

体内活性

In vivo, gliotoxin (5 mg/kg) reduces LTB4plasma levels and blocks peritoneal neutrophil infiltration in a mouse model of peritonitis induced by zymosan A . It also inhibits geranylgeranyltransferase I and farnesyltransferase (IC50s = 17 and 80 μM, respectively).8

别名

Gliotoxin-13C13;Gliotoxin-13C13

储存和溶解度

Acetonitrile:3 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years