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TAS 205
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TAS 205图片
CAS NO:1584160-52-0
包装:25 mg
市场价:10676元

产品介绍

产品描述

TAS 205 is an inhibitor of hematopoietic prostaglandin D synthase (H-PGDS; IC50= 55.8 nM).1It is selective for H-PGDS over lipocalin-type PGDS (L-PGDS) at 100 μM, as well as over enzyme and receptor panels at 10 μM. TAS 205 inhibits production of prostaglandin D2induced by A23187 in KU812 human and RBL-2H3 rat basophils with IC50values of 78.3 and 181.3 nM, respectively. It inhibits ovalbumin-induced nasal lavage fluid eosinophil infiltration and late-phase nasal obstruction in an ovalbumin-sensitized guinea pig model of allergic rhinitis when administered at a dose of 30 mg/kg.

Cas No.

1584160-52-0

分子式

C27H38N6O5

分子量

526.63

别名

TAS 205

储存和溶解度

DMSO:30 mg/mL
DMF:30 mg/mL
Ethanol:30 mg/mL
Ethanol:PBS (pH 7.2) (1:4):0.20 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years