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DMPO
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DMPO图片
CAS NO:3317-61-1
包装与价格:
包装价格(元)
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议

产品名称
5,5-Dimethyl-1-pyrroline N-oxide
5,5-二甲基-1-吡咯啉-N-氧化物
产品介绍
DMPO 是一种细胞渗透性亲水自旋诱捕剂,可用于超氧化物检测。

产品描述

DMPO is a kind of water-soluble nitric oxide spin trap, which allows the measurement of oxygen-centered free radicals in biological systems at room temperature using electron spin resonance. It has a high reaction rate constant for superoxide and hydroxyl radicals and distinguishes simultaneously among a variety of important biologically generated free radicals.

体外活性

In vitro, It was demonstrated in red blood cells and in hamster V79 cells that the DMPO spin adducts of ·O2? and ·OH are metabolized very rapidly so that even if formed, they may not be detected in many experiments with cells [1].

体内活性

When DMPO perfused the heart at 100 μm/L, it attenuated the development of reperfusion arrhythmias during the first 10 min of reperfusion and improved the functional recovery of the heart during reperfusion. Without treatment, 55% of hearts showed irreversible ventricular fibrillation, and this was completely prevented by DMPO, due to its function of traping·O2? and ·OH radicals [2].

Cas No.

3317-61-1

分子式

C6H11NO

分子量

113.16

别名

5,5-Dimethyl-1-pyrroline N-oxide;5,5-二甲基-1-吡咯啉-N-氧化物;DMPO

储存和溶解度

DMSO:12mg/mL (106.04 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years