2',3'-Dideoxyadenosine 是HIV复制抑制剂,具有抗逆转录病毒活性和抗病毒的作用[1]。
产品描述
2',3'-Dideoxyadenosine is an inhibitor of HIV replication with antiretroviral activity and antiviral efficacy [1].
体外活性
2',3'-Dideoxyadenosine shows inhibition of HIV-1 and simian immunodeficiency virus (SIV) in MT-4 cells with EC 50 s of 5.27 and 5.3 μM, respectively. 2',3'-Dideoxyadenosine inhibits HIV-1 and HIV-2 in human T-lymphocyte CEM cells with EC 50 s of 4 μM and 8 μM, respectively. 2',3'-Dideoxyadenosine inhibits HIV-1 and HIV-2 in Molt 4/C8 cells with EC 50 s of 4 μM and 5.5 μM, respectively. 2',3'-Dideoxyadenosine inhibits HIV-1 and HIV-2 in C8166 cells with EC 50 s of 17 μM and 22 μM, respectively. 2',3'-Dideoxyadenosine inhibits murine sarcoma virus (MSV) in C3H/3T3 cells with an EC 50 of 24 μM [1].
Cas No.
4097-22-7
分子式
C10H13N5O2
分子量
235.24
别名
Dideoxyadenosine
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years