NOD2 antagonist 1 (compound 32) 是一种有效且具有选择性的NOD2拮抗剂,IC50为 5.23 μM。NOD2 antagonist 1 可在 THP-1 细胞中抑制 Muramyl dipeptide (MDP) 诱导的 IL-8 分泌,也在 PBMCs 细胞中抑制 MDP 诱导的 IL-6、IL-10 和 TNF-α 的水平升高。
产品描述
NOD2 antagonist 1 (compound 32) is a potent and selective NOD2 antagonist with an IC 50 of 5.23 μM. NOD2 antagonist 1 inhibits Muramyl dipeptide (MDP)-induced IL-8 secretion in THP-1 cells and inhibits MDP-induced IL-6, IL-10, TNF-α release in PBMCs [1].
Cas No.
2411441-54-6
分子式
C26H26N4O3S
分子量
474.57
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years