p-cumylphenol 可治疗新生大鼠肾小管囊肿形成。
产品描述
p-cumylphenol can treat R enal Tubular Cyst Formation in Newborn Rats.
体内活性
P-cumylphenol induced multiple renal cysts that developed in the collecting ducts of the outer medulla in neonatal rats, and it is suggested that epithelial cell proliferation may play some roles in the induction of cystic lesions.
动物实验
Fifteen animals per sex were treated orally with 300 mg/kg/day of p-cumylphenol for up to 18 days from postnatal day (PND) 4 and were sacrificed on PNDs 8, 12, 19 and 22 and after a 7 day recovery period. On PNDs 8 and 12, slight dilatation of the collecting ducts was frequently observed in the medulla and slight papillary necrosis was also noted in some cases. These dilated collecting ducts were lined with slightly hyperplastic epithelial cells. On PNDs 19 and 22, multiple large cystic changes arising from the collecting ducts in the outer medulla were seen.
Cas No.
599-64-4
分子式
C15H16O
分子量
212.292
别名
p-cumylphenol
储存和溶解度
DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years