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JC-171
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
JC-171图片
CAS NO:2112809-98-8
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍

产品描述

JC-171 is a selective NLRP3 inflammasome inhibitor, with an IC50 of 8.45 μM for inhibiting LPS/ATP-induced interleukin-1β (IL-1β) release from J774A.1 macrophages[1].

体外活性

JC-171 (0-100 μM) blocks NLRP3 inflammasome activation and IL-1β production in primary macrophages dose dependently[1]. Cell Viability Assay[1] Cell Line: J774A.1 murine macrophage cells

体内活性

JC-171 treatment delays the progression and reduces the severity of experimental autoimmune encephalomyelitis (EAE) in mouse[1]. Animal Model: Mice immunized subcutaneously with 200 μg Myelin oligodendrocyte glycoprotein (MOG) 35-55 peptide emulsified in Complete Freund's Adjuvant (CFA) on day 0 followed by injection of 200 ng of pertussis toxin.

Cas No.

2112809-98-8

分子式

C16H17ClN2O5S

分子量

384.83

别名

JC-171

储存和溶解度

DMSO:250 mg/mL (649.64 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years