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cGAMP
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
cGAMP图片
CAS NO:849214-04-6
包装:5 mg
市场价:7000元

产品名称
3',3'-cGAMP
Cyclic GMP-AMP
产品介绍

产品描述

cGAMP is an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. It also is a STING ligand.

体外活性

cGAMP directly activates murine and human dendritic cells in vitro. cGAMP promotes the antigen-specific proliferation capacity of spleen cells in mice [2]. On stimulation with cGAMP, fibroblasts from the patients showed increased transcription of IFNB1 but not of the genes encoding IL-1, IL-6, or TNF [3]. cGAMP activates the endoplasmic reticulum (ER)-resident receptor STING, thereby inducing an antiviral state and the secretion of type I IFNs [4].

体内活性

cGAMP stimulates the antigen-specific cytokine production by spleen cells of immunized mice [2].

Cas No.

849214-04-6

分子式

C20H24N10O13P2

分子量

674.41

别名

3',3'-cGAMP;Cyclic GMP-AMP;cGAMP

储存和溶解度

H2O:20 mg/mL (29.66 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years