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Phen-DC3 Trifluoromethanesulfonate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Phen-DC3 Trifluoromethanesulfonate图片
CAS NO:929895-45-4
包装:50 mg
市场价:20217元

产品名称
Phen-DC3 Triflate
产品介绍

产品描述

Phen-DC3 Trifluoromethanesulfonate is a G-quadruplex (G4) specific ligand. It also can inhibit FANCJ and DinG helicases (IC50s: 65±6 and 50±10 nM, respectively).

体外活性

The CEB25-L111(T) array is stable in WT cells, it becomes unstable upon addition of Phen-DC3 Trifluoromethanesulfonate or deletion of PIF1. A CEB1-WT array is rather stable but undergoes frequent rearrangements upon addition of 10 μM Phen-DC3 Trifluoromethanesulfonate (Phen-DC3) in WT cells. It is found that the c-Myc allele displays significant destabilization upon Phen-DC3 Trifluoromethanesulfonate treatment and PIF1 deletion. It is also highly destabilized in the presence of Phen-DC3 Trifluoromethanesulfonate or in the absence of PIF1. The CEB1-loop CEB25 allele remaines fully stable in both PIF1-treated and WT cells[2].

Cas No.

929895-45-4

分子式

C36H26F6N6O8S2

分子量

848.75

别名

Phen-DC3 Triflate;Phen-DC3 Trifluoromethanesulfonate

储存和溶解度

DMSO:34 mg/mL (40.06 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years