产品描述
ST-193 hydrochloride is a potent inhibitor of broad-spectrum arenavirus(Guanarito, Junin, Lassa and Machupo virus with IC50 values of 0.44, 0.62, 1.4 and 3.1 nM, respectively).
体外活性
LASV pseudotypes(IC50 of 1.6 nM)inhibited by ST-193 . ST-193 inhibits pseudotypes generated with other arenavirus envelopes as well, including the remaining four commonly associated with hemorrhagic fever (IC50s for Junín, Machupo, Guanarito, and Sabiá were in the 0.2 to 12 nM range)[2].
体内活性
Compared to the ribavirin or vehicle groups, ST-193-treated animals exhibit fewer signs of disease and enhance survival . Body temperatures in all groups are elevated by day 9, but returned to normal by day 19 postinfection in the majority of ST-193-treated animals. ST-193 treatment mediates a 2- to 3-log reduction in viremia relative to vehicle-treated controls. The overall survival rate for the ST-193-treated guinea pigs is 62.5% (10/16) compared with 0% in the ribavirin (0/8) and vehicle (0/7) groups[3].
Cas No.
T13006L
分子式
C24H26ClN3O
分子量
407.94
别名
ST-193 hydrochloride;ST-193 hydrochloride (489416-12-8 free base)
储存和溶解度
DMSO:150 mg/mL (367.70 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years