Darodipine 是钙离子通道的有效拮抗剂。

Darodipine is a dihydropyridine type Ca+2 antagonist.

Darodipine may reduce neuronal cytoskeletal changes occurring in aging and in neurodegenerative disorders. Darodipine (10 mg/kg; 6-month (from the 18th to the 24th month of life); p.o.) treatment restores in part the expression of 200 kDa-NF subunit immunoreactivity in the cerebellar cortex [2]. Treatment with darodipine increases the number and the average length of alkaline phosphatase-reactive capillaries and reduces the intercapillary distance and the diameter of cerebral capillaries in old rats. The pericapillary microrenvironment of the Ammon's horn is the most sensitive to treatment with darodipine [1].

72803-02-2

C19H21N3O5

371.39

PY-108068;PY 108-068;达罗地平;Darodipine

DMSO:60 mg/ml (161.56 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years