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3,5-dimethyl PIT-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
3,5-dimethyl PIT-1图片
CAS NO:701947-53-7
包装:50 mg
市场价:7095元

产品介绍

产品描述

PtdIns-(3,4,5)-P3 (PIP3) serves as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains such as phosphatidylinositol 3-kinase (PI3K) or PTEN. Protein binding to PIP3 is important for cytoskeletal rearrangement and membrane trafficking and initiates an intricate signaling cascade that has been implicated in cancer. 3,5-dimethyl PIT-1 is a dimethyl analog of PIT-1, the selective inhibitor of PIP3/Akt PH domain binding, that is designed for more favorable solubility in vivo. 3,5-dimethyl PIT-1 inhibits PI3K/Akt signaling (IC50 = 27 μM), suppressing PI3K-PDK1-Akt-dependent phosphorylation, which has been shown to reduce cell viability and induce apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 36 μM). 4T1 breast cancer growth is significantly attenuated in BALB/c mice with a dose of 1 mg/kg of 3,5-dimethyl PIT-1 per day.

Cas No.

701947-53-7

分子式

C16H15N3O4S

分子量

345.37

别名

3,5-dimethyl PIT-1

储存和溶解度

Ethanol:0.2 mg/mL
DMF:30 mg/mL
DMSO:20 mg/mL
DMF:PBS(pH 7.2)(1:1):0.5 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years