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FEN1-IN-4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
FEN1-IN-4图片
CAS NO:1995893-58-7
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
FEN1 Inhibitor C2
产品介绍
FEN1 Inhibitor C2 是人类皮瓣内切核酸酶-1 (hFEN1) 抑制剂。

产品描述

FEN1-IN-4 is an inhibitor of human flap endonuclease-1 (hFEN1)

体外活性

FEN1 Inhibitor C2 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a, both frequently mutated in colorectal cancers.?FEN1 has also emerged as a potential chemosensitizing target due to its role in LP-BER since it is critical for repair of MMS (methyl methanesulfonate)-induced alkylation damage, and its knockdown or inhibition increases sensitivity to TMZ (temozolomide) in glioblastoma and colorectal cancer cell lines.

Cas No.

1995893-58-7

分子式

C12H12N2O3

分子量

232.239

别名

FEN1 Inhibitor C2;FEN1-IN-4

储存和溶解度

DMSO:100 mg/mL (430.59 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years