您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > ALE-0540
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
ALE-0540
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ALE-0540图片
CAS NO:234779-34-1
包装与价格:
包装价格(元)
1 mg电议
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议

产品介绍
ALE-0540是一种非肽类杂环分子,可抑制NGF与p75和TrkA的结合,以及TrkA受体介导的信号转导和生物反应。

产品描述

ALE-0540 is a nonpeptidic heterocyclic molecule that inhibits the binding of NGF to p75 and TrkA, as well as signal transduction and biological responses mediated by TrkA receptors.

体内活性

Either i.p. or i.th. administration of ALE-0540 in rats produced antiallodynia in the L5/L6 ligation model of neuropathic pain. The calculated A50 values (and 95% confidence intervals) for ALE-0540 administered i.p. and i.th. were 38 (17.5–83) mg/kg and 34.6 (17.3–69.4) mg, respectively. ALE-0540 given i.th., at doses of 30 and 60 mg, also blocked tactile allodynia in the thermal sensitization model.

Cas No.

234779-34-1

分子式

C14H11N3O5

分子量

301.25

别名

ALE-0540

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years