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NSC745885
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NSC745885图片
CAS NO:4219-52-7
包装与价格:
包装价格(元)
50 mg电议
100 mg电议

产品介绍

产品描述

NSC745885 is an effective down-regulator of EZH2 via proteasome-mediated degradation. NSC745885 is also an effective anti-tumor agent that displays selective toxicity against multiple cancer cell lines but not normal cells. NSC745885 offers possibilities for the study of advanced bladder and oral squamous cell carcinoma (OSCC) cancers.

体外活性

NSC745885 (0.5-4 μM; 24 hours) enhances annexin V positive cells in a dose-dependent manner, and the differences appear as a dose-dependent manner. NSC745885 (0.5-2 μM; 24 or 48 hours) reduces XIAP protein levels and increases protein levels both as a dose-dependent manner in SAS cells. NSC745885 (0.5-4 μM; 24, 48 or 72 hours) has a growth inhibitory or death-promoting effect on the SAS cells, it significantly decreases the densities of cultured cells when compared with untreated cells. The IC50 of NSC745885 is 0.85 μM after 72 hours' treatment [1].

体内活性

NSC745885 (intraperitoneal injection; 2 mg/kg; once daily; 10 days) treatment obviously decreases tumor size when compared with the vehicle control. It shows higher safety than doxorubicin[1].

Cas No.

4219-52-7

分子式

C14H6N2O2S

分子量

266.28

别名

NSC745885

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years