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ERK Inhibitor
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ERK Inhibitor图片
CAS NO:1049738-54-6
包装:100 mg
市场价:7650元

产品介绍

产品描述

ERK inhibitor is a cell-permeable inhibitor that binds ERK2 near its docking domain (KD = 5 μM). This prevents its interaction with protein substrates without inhibiting catalytic activity. ERK inhibitor blocks ERK-specific phosphorylation of ribosomal S6 kinase-1 and ternary complex factor Elk-1 but does not affect ERK1/2 phosphorylation by MEK1/2. Presumably through its effects on ERK, ERK inhibitor completely prevents proliferation of HeLa cells (IC50 = 15-20 μM), A549 lung carcinoma cells (IC50 = 25 μM), Sum-159 estrogen receptor-negative breast cancer cells and HT1080 fibrosarcoma cells.

Cas No.

1049738-54-6

分子式

C14H17ClN2O3S

分子量

328.81

别名

ERK Inhibitor

储存和溶解度

DMSO:2 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years