TGFβ-IN-2 (Compound 9d) 作用于 NRK-49F 细胞，抑制 TGF-β 诱导的总胶原积累，IC50为 4.31 μM。TGFβ-IN-2 在体外抑制 TGF-β 诱导的 COL1A1、α-SMA 和 p-Smad3 蛋白表达。通过口服给药，TGFβ-IN-2可作为一种有潜力的体内抗纤维化有效化合物。

TGFβ-IN-2 (Compound 9d) inhibits TGF-β-induced total collagen accumulation in NRK-49F cells with the IC 50 of 4.31 μM. TGFβ-IN-2 suppresses the TGF-β-induced protein expression of COL1A1, α-SMA, and p-Smad3 in vitro. TGFβ-IN-2 can be used as a potential effective compound for anti-fibrosis in vivo by oral administration [1].

2387678-02-4

C22H22N2O4

378.42

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years