IWP-3 是高效的Wnt产生抑制剂(IC50= 40 nM)。IWP-3 抑制 Porcupine (Porcn) 功能，从而阻断 Wnt 蛋白的棕榈酰化。IWP-3 适度抑制 CK1γ3 和 CK1ε，不抑制 CK1α。

IWP-3 is an potent inhibitor of Wnt production with an IC 50 of 40 nM. IWP-3 inhibits Porcupine (Porcn) function thereby blocking palmitoylation of Wnt proteins. IWP-3 moderately inhibits CK1γ3 and CK1ε while not inhibit CK1α [1] [2].

687561-60-0

C22H17FN4O2S3

484.59

IWP-3

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years