PBD-150 是一种人谷氨酰胺酰基环化酶Y115E-Y117E变体的抑制剂，其Ki=490 nM。

PBD-150 is an inhibitor of human glutaminyl cyclase (hQC) Y115E-Y117E variant( ki : 490 nM)

A glutaminyl cyclase (QC) inhibitor, PBD150, was shown to be able to reduce the deposition of pyroglutamate-modified amyloid-β peptides in brain of transgenic mouse models of Alzheimer disease, leading to a significant improvement of learning and memory in those transgenic animals[1].

790663-33-1

C15H20N4O2S

320.41

PBD-150

DMSO:125 mg/mL (390.13 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years