DO34 is a highly potent and centrally active inhibitor of diacylglycerol lipase (IC50: 6 nM for DAGLα conversion of SAG to 2-AG).

DO34 also is a potent inhibitor of DAGLβ with IC50 of 3-8 nM [1].

DO34 could block the tonic CB1 activation. DO34 prevents fasting-induced refeeding of mice, this is typical cannabinoid CB1-receptor-mediated behavior. DO34 decreases brain 2-AG levels in a dose- and time-dependent manner [2]. AM251 obviously increases basal PF-EPSCs in MAGL-TKO mice. The effect of AM251 is blocked by the DAGL inhibitor DO34 [3].

1848233-58-8

C26H28F3N5O4

531.53

DO34

DMSO:100 mg/mL (188.14 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years