JAK3/BTK-IN-6 (化合物 14h) 是一种有效的BTK和JAK3双抑制剂，其IC50值分别为 0.6 和 0.4 nM。JAK3/BTK-IN-6 在人肝微粒体中具有良好的代谢稳定性。JAK3/BTK-IN-6 可用于血液和免疫疾病的研究。

JAK3/BTK-IN-6 (compound 14h) is a potent BTK and JAK3 dual inhibitor, with IC 50 values of 0.6 and 0.4 nM, respectively. JAK3/BTK-IN-6 shows good metabolic stability in human liver microsome. JAK3/BTK-IN-6 can be used for hematological and immune diseases research [1].

JAK3/BTK-IN-6 (compound 14h) shows antiproliferative activities against hematopoietic cells (Raji, Romas, HEL, Jeko-1, and OCI-LY10), with IC 50 values of 1.7, 0.5, 1.1, 0.5, and 1-10, respectively [1].

2243136-03-8

C21H17BF3N5O3

455.2

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years