AEG 3482 是一种有效的抗凋亡化合物，可诱导热休克蛋白 70 (HSP70) 的表达来抑制 JNK 活性。AEG 3482 通过直接结合 HSP90，从而促进 HSP70 和 HSP25 的 HSF1 依赖性表达。

AEG 3482 is a potent antiapoptotic compound. AEG 3482 inhibits Jun kinase (JNK) activity through induced expression of heat shock protein 70 (HSP70). AEG 3482 directly binds HSP90, thereby facilitating HSF1-dependent expression of HSP70 and HSP25.

AEG 3482 (0.3-30 μM; 2 d) inhibits nerve growth factor (NGF) withdrawal-induced death in SCG neurons, with an EC50 of ~20 μM. AEG 3482 (10-40 μM; 30 h) inhibits p75NTR- and NRAGE-mediated JNK activation in PC12 cells. AEG 3482 (1-80 μM; 40 h) inhibits p75NTR- and NRAGE- mediated apoptosis of PC12 cells in a dose-dependent manner[1].

63735-71-7

C10H8N4O2S2

280.33

AEG 3482

DMSO:200 mg/mL (713.4 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years