ZSET 1446 是一种 T 型钙通道激活剂,用于治疗各类阿尔茨海默病 (AD) 模型中的学习缺陷。
产品描述
ZSET-1446 is a T-type calcium channel activator potentially for the treatment of learning deficits in various types of Alzheimer disease (AD) models.
体内活性
ZSET1446 ameliorated cognitive deficits of SAMP8 after 4, 8, 12, and 16 weeks of treatment in a novel object recognition test.?ZSET1446 also reduced grading scores of SAMP8 after 16 weeks of treatment.?Further, 8-week treatment of ZSET1446 significantly reduced the total number of Aβ-positive granules in the hippocampus.?ZSET1446 shows ameliorating effects on SAMP8 partly due to the suppression of an increase of Aβ-deposition in the hippocampus[1].
动物实验
ZSET1446 was administered in drinking water at estimated doses of 0.002, 0.01, and 0.1 mg/kg per day from the age of 8 months mouse.?The SAMP8 at the age of 8 months showed cognitive impairment in a novel object recognition task compared with young SAMP8 at the age of 8 weeks.?Further, grading scores were gradually increased from 9 to 12 months and Aβ-like immunoreactivity in the hippocampus was increased at the age of 10 months[1].
Cas No.
887603-94-3
分子式
C15H12N2O
分子量
236.274
别名
ST-101;ZSET-1446;ZSET1446
储存和溶解度
DMSO:29 mg/ml(122.74 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years