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NVP-CGM097 sulfate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NVP-CGM097 sulfate图片
CAS NO:1313367-56-4
包装与价格:
包装价格(元)
50 mg电议
100 mg电议

产品名称
CGM097 sulfate
产品介绍

产品描述

NVP-CGM097 sulfate is a potent and selective inhibitor of MDM2 (hMDM2, IC50 of 1.7±0.1 nM).

体外活性

NVP-CGM097 is able to significantly redistribute wild-type p53 into the cell nucleus with an IC50 of 0.224 μM, demonstrating its ability to inhibit the p53:MDM2 interaction in living cells.?NVP-CGM097 significantly inhibits the proliferation of cells expressing wild-type p53, while sparing the p53 null cells with a 35-58-fold difference.?NVP-CGM097 inhibtis HCT116 (p53WT/WT) with IC50 of 454±136 nM[1].

Cas No.

1313367-56-4

分子式

C38H49ClN4O8S

分子量

757.34

别名

CGM097 sulfate;NVP-CGM097 sulfate

储存和溶解度

H2O:140 mg/mL (184.86 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years