产品描述
PhiKan 083 hydrochloride is a carbazole derivative. Which binds to the surface cavity and stabilizes Y220C (Kd: 167 μM). It also a relative binding affinity (Kd) of 150 μM in Ln229 cells.
体外活性
PhiKan 083 slows down its thermal denaturation rate. PhiKan 083 shows a relative binding affinity (Kd) of 150 μM for p53Y220C in Ln229 cells. PhiKan 083 (100 μM) in combination with NSC 123127 (1 μM) increases the pro-apoptotic activity in all variants of Ln229 cells (p53wt, p53Y220C, p53G245S, p53R282W). PhiKan 083 (125 μM, 48 hours) decreases the cell viability of engineered variants of Ln229 cells [2][3].
Cas No.
1050480-30-2
分子式
C16H19ClN2
分子量
274.79
别名
PhiKan 083 hydrochloride
储存和溶解度
H2O:2 mg/mL (7.28 mM),Need ultrasonic and warming
Powder: -20°C for 3 years
In solvent: -80°C for 2 years