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PhiKan 083 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PhiKan 083 hydrochloride图片
CAS NO:1050480-30-2
包装:200 mg
市场价:9545元

产品介绍

产品描述

PhiKan 083 hydrochloride is a carbazole derivative. Which binds to the surface cavity and stabilizes Y220C (Kd: 167 μM). It also a relative binding affinity (Kd) of 150 μM in Ln229 cells.

体外活性

PhiKan 083 slows down its thermal denaturation rate. PhiKan 083 shows a relative binding affinity (Kd) of 150 μM for p53Y220C in Ln229 cells. PhiKan 083 (100 μM) in combination with NSC 123127 (1 μM) increases the pro-apoptotic activity in all variants of Ln229 cells (p53wt, p53Y220C, p53G245S, p53R282W). PhiKan 083 (125 μM, 48 hours) decreases the cell viability of engineered variants of Ln229 cells [2][3].

Cas No.

1050480-30-2

分子式

C16H19ClN2

分子量

274.79

别名

PhiKan 083 hydrochloride

储存和溶解度

H2O:2 mg/mL (7.28 mM),Need ultrasonic and warming
Powder: -20°C for 3 years
In solvent: -80°C for 2 years