SM-433 hydrochlorid 是一种 Smac 模拟物,是一种凋亡抑制蛋白(IAPs)的抑制剂发挥作用。SM-433 hydrochlorid 表现出强结合亲和力 XIAP BIR3 蛋白,IC50<1 μM (详细信息来自专利 WO2008128171A2)。
产品描述
SM-433 hydrochlorid, a Smac mimetic, function as inhibitor of inhibitor of apoptosis proteins (IAPs). SM-433 hydrochlorid exhibits strong binding affinity XIAP BIR3 protein with an IC 50<1 μM (patent WO2008128171A2) [1].
体外活性
SM-433 hydrochlorid exhibits strong inhibitory activity against MDA-MB -2131 human breast cancer cells and SK-OV-3 ovarian cancer cells (IC 50 s<10 μM, respectively) [1].
分子式
C32H44ClN5O4
分子量
598.18
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years