您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Alfuzosin hydrochloride
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Alfuzosin hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Alfuzosin hydrochloride图片
CAS NO:81403-68-1
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
SL 77499-10
Alfuzosin HCl
盐酸阿夫唑嗪
产品介绍
Alfuzosin hydrochloride 是一种 α1 肾上腺素受体拮抗剂,可用于良性前列腺增生(BPH)的研究。

产品描述

Alfuzosin hydrochloride is an α1 adrenergic receptor antagonist. It applies to treat benign prostatic hyperplasia (BPH).

体外活性

Alfuzosin significantly increases whole-cell peak sodium (hNa(v)1.5) current, increases the probability of late hNa(v)1.5 single-channel openings, and significantly shortens the slow time constant for recovery from inactivation. Alfuzosin also increases hNa(v)1.5 burst duration and number of openings per burst between 2- and 3-fold. [1] Alfuzosin shows a concentration-dependent relaxing effect on rabbit corpus cavernosum (CC) pre-contracted by 10 mM phenylephrine. [2]

体内活性

Alfuzosin (300 nM) significantly prolongs action potential duration (APD)(60) in rabbit Purkinje fibers and QT in isolated rabbit hearts. [1] Alfuzosin enhances the number and amplitude of erections induced by apomorphine in spontaneous hypertensive rats (SHR). [3] Alfuzosin behaves as an alpha-adrenergic antagonist blocking the contractions induced by exogenous noradrenaline without altering spikes in both portions of the vas deferens. [4] Alfuzosin (0.03-0.3 mg kg-1, i.v.) markedly inhibits pressor responses produced by the alpha 1-selective agonist, Cirazoline but inhibits only slightly responses to the alpha 2-selective agonist, UK 14,304, in the pithed rat. Alfuzosin (1 mg kg-1, i.v.) has minimal effects against responses mediated by stimulation of prejunctional alpha 2-receptors (UK 14,304-induced inhibition of sympathetic tachycardia). Alfuzosin (0.001-1 mg kg-1, i.v.) and Prazosin (0.001-0.3 mg kg-1, i.v.) produces dose-related inhibition of the increases in urethral pressure caused by stimulation of sympathetic hypogastric nerves in the anaesthetized cat. [5]

Cas No.

81403-68-1

分子式

C19H28ClN5O4

分子量

425.91

别名

SL 77499-10;Alfuzosin HCl;盐酸阿夫唑嗪;Alfuzosin hydrochloride

储存和溶解度

H2O:10.7 mg/mL (25 mM)
DMSO:10.7 mg/mL (25 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years