Alosetron Hydrochloride 是一种高选择性的 5-HT3 受体拮抗剂，可减轻清醒或麻醉犬直肠扩张的内脏伤害性效应，具有抗炎活性，用于肠易激综合征的研究。它阻断 5HT3 介导的豚鼠肌间和粘膜下神经元的快速去极化，IC50约为 55 nM。

Alosetron Hydrochloride is the hydrochloride salt form of alosetron, a potent and selective 5-HT3 receptor antagonist. Alosetron blocks the actions of serotonin at 5-HT3 sites in the peripheral nervous system, particularly on enteric and nociceptive sensory neurons, thereby affecting the regulation of visceral pain, decreasing gastrointestinal contraction and motility, and decreasing gastrointestinal secretions.

122852-69-1

C17H19ClN4O

330.82

Lotronex;GR 68755X;GR 68755C;盐酸阿洛司琼;GR 68755;Alosetron hydrochloride

DMSO:2.5 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years