ZK824190 hydrochloride 是一种口服有效的选择性尿激酶型纤溶酶原激活剂 (uPA) 抑制剂，可用于多发性硬化症的研究。ZK824190 hydrochloride 对 uPA，tPA 和 Plasmin 的IC50分别为 237，1600 和 1850 nM。

ZK824190 hydrochloride is an orally available and selective urokinase plasminogen activator ( uPA ) inhibitor as a potential treatment for multiple sclerosis. IC 50 s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively [1].

ZK824190 (2 mg/kg; PO; Rats with EAE model) exhibits a relatively high oral availability and a moderate half time (T 1/2 =2.8 h) [1].

2629177-12-2

C22H21ClF2N2O4

450.86

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years