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Migrastatin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Migrastatin图片
CAS NO:314245-65-3
包装:1 mg
市场价:8472元

产品介绍

产品描述

Migrastatin is a bacterial metabolite that has been found inStreptomyceswith antimuscarinic and anticancer activities.1,2It binds to M1-5muscarinic acetylcholine receptors (Kis = >200, 200, 31, 43, and >200 μM, respectively) and inhibits calcium mobilization induced by carbamoylcholine in SK-N-SH cells (IC50= 28 μM), as well as in primary rat bladder smooth muscle cells.1Migrastatin inhibits the migration of EC17 esophageal cancer cells in a wound healing assay (IC50= 10 μg/ml) and 4T1 mouse mammary carcinoma cells in a chamber cell migration assay (IC50= 29 μM).2It enhances cytotoxicity induced by vinblastine in vincristine-resistant P388/VCR cells.3

Cas No.

314245-65-3

分子式

C27H39NO7

分子量

489.6

别名

Migrastatin

储存和溶解度

DMSO:Soluble
DMF:Soluble
Methanol:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years