您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > 2-deoxy-D-Glucose-13C6
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
2-deoxy-D-Glucose-13C6
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
2-deoxy-D-Glucose-13C6图片
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议

产品介绍

产品描述

2-deoxy-D-Glucose-13C6is intended for use as an internal standard for the quantification of 2-deoxy-D-glucose by GC- or LC-MS. 2-deoxy-D-Glucose is a glucose antimetabolite and an inhibitor of glycolysis.1,2It inhibits hexokinase, the enzyme that converts glucose to glucose-6-phosphate, as well as phosphoglucose isomerase, the enzyme that converts glucose-6-phosphate to fructose-6-phosphate.32-deoxy-D-Glucose (16 mM) induces apoptosis in SK-BR-3 cells, as well as inhibits the growth of 143B osteosarcoma cells cultured under hypoxic conditions when used at a concentration of 2 mg/ml.4,5

体内活性

In vivo, 2-deoxy-D-glucose (500 mg/kg) reduces tumor growth in 143B osteosarcoma and MV522 non-small cell lung cancer mouse xenograft models when used alone or in combination with doxorubicin or paclitaxel .6

别名

2-deoxy-D-Glucose-13C6;2-deoxy-D-Glucose-13C6

储存和溶解度

H2O:Soluble
DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years