Hypromellose 是一种水溶性的亲水性非离子纤维素醚。

Hypromellose is a water-soluble hydrophilic, non-ionic cellulose ether.

Hypromellose (hydroxypropylmethylcellulose) has been used in sustained-release pharmaceutical products for many years. These polymers hydrate on contact with water to produce a viscous gel barrier within and surrounding the tablet when used in matrix tablets. The properties of hypromellose that affect the rate of drug release include the rate of diffusion of water into the dry polymer, the rate of hypromellose hydration and gel formation, the viscosity of the hydrated hypromellose, and rate of hypromellose gel erosion [2]. Hypromellose provides the release of a drug in a controlled manner, effectively increasing the duration of release of a drug to prolong its therapeutic effect [1].

Punctal occlusion using hypromellose 2% is a low-cost and safe additional treatment for dry eye. Fluorescein and rose bengal staining tests show that there was a significant reduction in signs after occlusion using hypromellose [3]. Hypromellose is effective in improving blood glucose metabolism and suppressing oxidative stress in mice fed with a high-fat diet. The antihyperglycemic and antioxidative effects of hypromellose could be partly attributed to the regulation of hepatic glucose-regulating enzyme activities and activation of the hepatic and erythrocyte antioxidant enzymes [4].

9004-65-3

C56H108O30

1261.45

HPMC;(Hydroxypropyl)methyl cellulose;Celacol HPM 5000;羟丙甲纤维素;Hypromellose

DMSO:22 mg/mL,Need ultrasonic
H2O:9 mg/mL,Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years