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nAChR agonist CMPI hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
nAChR agonist CMPI hydrochloride图片
CAS NO:2250025-94-4
包装:5 mg
市场价:7000元

产品介绍

产品描述

nAChR agonist CMPI hydrochloride is a potent and selective positive allosteric modulator (PAM) of nAChR containing a α4:α4 subunit interface. nAChR agonist CMPI hydrochloride enhances the response of (α4) 3 (β2) 2 nAChR to ACh (10 μM) with an EC 50 of 0.26 μM. nAChR agonist CMPI hydrochloride has potential for the research of nicotine dependence and many neuropsychiatric conditions associated with decreased brain cholinergic activity.

体外活性

CMPI (0.01-10 μM) potentiates (α4) 3 (β2) 2 (low ACh sensitivity) but not (α4) 2 (β2) 3 (high ACh sensitivity) nAChRs in Xenopus laevis oocytes[1]. CMPI (0.01-10 μM) inhibits (α4) 2 (β2) 3 , human muscle and Torpedo nAChRs with IC 50 s of 0.6, 0.7 and 0.2 μM, respectively in Xenopus oocytes[1].

Cas No.

2250025-94-4

分子式

C18H20Cl2N4O

分子量

379.29

别名

nAChR agonist CMPI hydrochloride

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years