Piperilate (Pipethanate) 是希泽平衍生物 PAF 拮抗剂与抗胆碱能药物混合物的一种，可用于支气管哮喘研究。Piperilate 还能引起低血压，拯救被有机磷中毒的老鼠。

Piperilate (Pipethanate) is one of the mixtures of hetrazepine derivative PAF antagonists with anticholinergics, can be used for bronchial asthma research. Piperilate also causes hypotension and rescues mice poisoned by the organophosphates [1] [2] [3].

Piperilate (11.3 mg/kg, 29.42 mg/kg; i.p.; single dose) shows anticholinergic activity, and (30 mg/kg; i.p.; single dose) exerts efficacy in mice poisoned by the organophosphates [1]. Piperilate (1 mg/kg; i.v.) causes hypotension in rabbit which is not blocked by dichloroisoproterenol or Atropine [2]. Piperilate (3 mg/kg; i.v.) decreases respiration and heart rate of test rabbits, blocks the Adrenaline -induced constriction of an isolated rabbit auricle preparation [2]. Animal Model: Male albino mice (18-22 g) [1] Dosage: 11.3 mg/kg, 29.42 mg/kg Administration: Intraperitoneal injection; single dose Result: Showed anticholinergic activity with EC 50 values of 11.33 mg/kg (antagonism of oxotremorine induced salivation) and 29.42 mg/kg (antagonism of oxotremorine induced tremor) in mice.

4546-39-8

C21H25NO3

339.43

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years