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Piperilate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:4546-39-8
包装与价格:
包装价格(元)
5 mg电议
50 mg电议
100 mg电议

产品介绍
Piperilate (Pipethanate) 是希泽平衍生物 PAF 拮抗剂与抗胆碱能药物混合物的一种,可用于支气管哮喘研究。Piperilate 还能引起低血压,拯救被有机磷中毒的老鼠。

产品描述

Piperilate (Pipethanate) is one of the mixtures of hetrazepine derivative PAF antagonists with anticholinergics, can be used for bronchial asthma research. Piperilate also causes hypotension and rescues mice poisoned by the organophosphates [1] [2] [3].

体内活性

Piperilate (11.3 mg/kg, 29.42 mg/kg; i.p.; single dose) shows anticholinergic activity, and (30 mg/kg; i.p.; single dose) exerts efficacy in mice poisoned by the organophosphates [1]. Piperilate (1 mg/kg; i.v.) causes hypotension in rabbit which is not blocked by dichloroisoproterenol or Atropine [2]. Piperilate (3 mg/kg; i.v.) decreases respiration and heart rate of test rabbits, blocks the Adrenaline -induced constriction of an isolated rabbit auricle preparation [2]. Animal Model: Male albino mice (18-22 g) [1] Dosage: 11.3 mg/kg, 29.42 mg/kg Administration: Intraperitoneal injection; single dose Result: Showed anticholinergic activity with EC 50 values of 11.33 mg/kg (antagonism of oxotremorine induced salivation) and 29.42 mg/kg (antagonism of oxotremorine induced tremor) in mice.

Cas No.

4546-39-8

分子式

C21H25NO3

分子量

339.43

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years