6-O-desmethyl Donepezil is an active metabolite of the acetylcholinesterase inhibitor donepezil . It is formed through dealkylation by the cytochrome P450 (CYP) isoform CYP2D6. It inhibits human ether a go-go (hERG) channels (IC50 = 1.5 μM in HEK293 cells expressing hERG).

120013-56-1

C23H27NO3

365.47

6-O-desmethyl Donepezil

Chloroform:Soluble
Methanol:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years