Z-Asp-CH2-DCB 是广谱半胱天冬酶的不可逆抑制剂。

Z-Asp-CH2-DCB is an irreversible inhibitor of broad spectrum caspase.

Z-Asp-CH2-DCB (10-100 μM) dose-dependently blocks the production of IL-1β, TNF-α, IL-6, and IFN-γ in SEB-stimulated (200 ng) PBMC. Z-Asp-CH2-DCB suppresses the production of the chemokines MCP-1, MIP-1α, and MIP-1β[1]. Z-Asp-CH2-DCB inhibits TSST-1-activated PBMC and reduces IL-1β, IL-6, TNF-α, IFN-γ, MCP-1, MIP-1α, and MIP-1β to 10, 36, 25, 10, 11, 25, and 30%, respectively[1].

SU5416-induced septal cell apoptosis prevented byZ-Asp-CH2-DCB (1 mg; i.p.; every day for 3 weeks)[1].

153088-73-4

C20H17Cl2NO7

454.26

Z-Asp-CH2-DCB

DMSO:95.4mg/mL (210mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years