您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > BMS 599626 dihydrochloride(714971-09-2 free base)
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
BMS 599626 dihydrochloride(714971-09-2 free base)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BMS 599626 dihydrochloride(714971-09-2 free base)图片
包装与价格:
包装价格(元)
5 mg电议
25 mg电议
100 mg电议

产品名称
BMS 599626 dihydrochloride
BMS 599626 dihydrochloride (714971-09-2 free base)
产品介绍

产品描述

BMS 599626 dihydrochloride is a potent and selective EGFR and ErbB2 inhibitor. BMS-599626 inhibited HER4 (IC50: 190 nM). In Sal2, N87, and GEO tumor cells, BMS-599626 inhibited phosphorylation of HER1 and HER2 in a dose-dependent way and inhibited cell proliferation. In AU565 breast cancer cells, BMS-599626 (1μM) inhibited HER1/HER2 heterodimer formation. In tumor cells that forming HER1/HER2 heterodimers, BMS-599626 inhibited heterodimerization [1][2].

体外活性

In the L2987 human lung tumors xenograft models, BMS-599626 (60 mg/kg) inhibited and delayed tumor growth in a dose-dependent way [1].

Cas No.

T22610

分子式

C27H27FN8O3·2HCl

分子量

603.48

别名

BMS 599626 dihydrochloride;BMS 599626 dihydrochloride (714971-09-2 free base)

储存和溶解度

DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years