您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > 1-[2-(azocan-1-yl)ethyl]guanidine
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
1-[2-(azocan-1-yl)ethyl]guanidine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:55-65-2
包装与价格:
包装价格(元)
100 mg电议
500 mg电议

产品介绍
Guanethidine于1959年合成,被认为可以通过干扰神经节后交感神经纤维中的化学递质物质的代谢来降低血压。

产品描述

Guanethidine sulphate, synthesized in 1959, is thought to lowing blood pressure by interfering with the metabolism of chemical transmitter substances in post-ganglionic sympathetic nerve fibres.

体外活性

Sympathetic fibers ablation is associated with a loss of rat endothelial cell marker (RECA), but no significant effect of guanethidine was found on the survival of endothelial cells and mesenchymal stem cells in vitro [1].

体内活性

Guanethidine (30 mg/kg, s.c., 1 h) does not affect IL-18 hypernociception in TNFR1 (-/-) mice as a sympathetic blocker [2]. Animal Model: Wild-type (WT) Balb/c,TNFR1 (-/-) and IFN -γ -γ (-/-) mice [2]. Dosage: 30 mg/kg Administration: Guanethidine (30 mg/kg, s.c., 1 h, diluted in saline) Result: Pre-treatment with guanethidine (sympathetic blocker) unaffected IL-18 hypernociception in TNFR1 (-/-) mice.

Cas No.

55-65-2

分子式

C10H22N4

分子量

198.31

别名

1-[2-(azocan-1-yl)ethyl]guanidine

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years