Potent and selective β-secretase (BACE) inhibitor (IC50 values are 10.2 and 20.3 nM for human BACE2 and BACE1, respectively). Displays >5,000-fold selectivity for BACE over other proteases including cathepsin D, pepsin and renin. Inhibits Aβ1-40 and Aβ1-42 production in cells expressing mutated APP. Reduces hippocampal and cortical Aβ and sAPPβ levels in an Alzheimer's disease mouse model.

1262036-49-6

C18H17ClF2N4O2S

426.87

LY 2886721 Hydrochloride

DMSO:42.69 mg/mL(100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years